Hi Carl, yes if you’re looking to win the week (vs win the season) you would want to take that risk. I went with Denver for 16 last week in one pool and when they pulled the upset I won the week. You will lose much of the time, but hopefully you’d hit 4-5 times a year and be in the money.
Check out this article: https://confidencepoolpicks.com/nfl-weekly-confidence-pool-picks-the-basics/