Welcome to Week 2! Two money picks hit in Week 1: the Indianapolis Colts and Los Angeles Chargers. Congratulations to everyone who backed them. Check out this week’s matchups and updated picks. Let’s keep the momentum going in Week 2!

Scores from last week:

• Base pick: 117
• High Risk: 102
• Med Risk: 101
• Some Risk: 87

Here are this week’s updated base picks.

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Keep an eye on our $ Score metrics to uncover the top-value picks and maximize your points. With the competition tighter than ever, every pick matters. Week 2 is here—let’s build on our start and set the tone for a winning 2025 season!

See our NFL Weekly Confidence Pool Picks: The Basics post or How to make confidence pool picks for beginners – 2023 update video for for more info on how to use these picks.

[Updated Picks on 09/12/25]

Higher Risk Picks (Bright Green):

• Jacksonville Jaguars over Cincinnati Bengals: 37% win probability, 6% pick-rate
• Las Vegas Raiders over Los Angeles Chargers: 37% win probability, 8% pick-rate
• Tennessee Titans over Los Angeles Rams: 30% win probability, 3% pick-rate
• New York Giants over Dallas Cowboys: 30% win probability, 3% pick-rate
• New York Jets over Buffalo Bills: 26% win probability, 2% pick-rate
• Carolina Panthers over Arizona Cardinals: 26% win probability, 3% pick-rate

For a bold high risk pick, consider the Jacksonville Jaguars over the Cincinnati Bengals. With a 37% win probability and just a 6% pick-rate, this choice offers significant upside for those looking to separate from the pack. If the Jaguars pull off the upset, it could provide a major boost in the standings.

Medium Risk Picks (Dark Green):

• Seattle Seahawks over Pittsburgh Steelers: 40% win probability, 10% pick-rate
• New Orleans Saints over San Francisco 49ers: 39% win probability, 10% pick-rate
• Washington Commanders over Green Bay Packers: 37% win probability, 16% pick-rate [*Finished Game]
• Atlanta Falcons over Minnesota Vikings: 38% win probability, 12% pick-rate

For a medium risk pick, the Seattle Seahawks over the Pittsburgh Steelers stands out. With a 40% win probability and a 10% pick-rate, this option balances risk and reward, offering a solid opportunity to gain ground without taking on the highest level of risk. Choosing the Seahawks could give you an edge if they come through with a win.

As Week 2 gets underway, now is the perfect time to refine your strategies and make every pick count.

Suggested picks by risk

See our NFL Weekly Confidence Pool Picks: The Basics post or How to make NFL Pick ‘Em Confidence Pool Picks – step by step video for for more info.